FK-506

FK-506, Tacrolimus, FR-900506, Prograf. A macrolide immunosuppressant isolated from Streptomyces tsukubaensis.

Sku #Product NameProduct SizePriceQTY
1100060012 FK-506 1 mg 1 mg $33.00 USD
1100060052 FK-506 5 mg 5 mg $109.00 USD
1100060102 FK-506 10 mg 10 mg $185.00 USD
 

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Molecular Formula: C44H69NO12 H2O
Molecular Weight: 822.03 g/mol
CAS Number: 109581-93-3
Solubility: Soluble in DMSO or100% ethanol, methanol, ethyl acetate or acetone: insoluble in water.
Purity: 98%
Storage: -20ºC
Applications: Immunosupressive properties very similar to cyclosporine, but ten to a hundred times more potent

Material Safety Data Sheet

Date:Oct 21,2015

1. PRODUCT AND COMPANY IDENTIFICATION

1.1 Product identifier

Product name: FK-506

Catalog No:1100060012,1100060052,1100060102

1.2 Relevant identified uses of the substance or mixture and uses advised against

For research use only.

1.3 Details of the supplier of the safety data sheet

Company:Eton Bioscience Inc

TollFree:1-800-758-1630

Tel:1-800-758-1630

Fax:1-800-507-2912

1.4 Emergency telephone number

1-800-758-1630

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Acute Toxicity-Oral,Category 3

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal Word

Danger

Hazard Statement

H301

Toxic if swallowed

Precautionary statement

P264

Wash skin thoroughly after handling

P302+P310

IF SWALLOED: immediately call a POISON CENTER or doctor/physician

P330

Rinse mouth

P501

Dispose of contents/container to an approved waste disposal plant

2.3 Other hazards

None

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Molecular Formula: C44H69NO12 H2O

Molecular Weight:822.03g/mol

CAS No:109581-93-3

4. FIRST AID MEASURES

4.1 Description of first aid measures

Eye contact

Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician

Skin Contact

Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician

Inhalation

If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration

Ingestion

If swallowed, wash out mouth with copious amounts of water; call a physician

4.2 Most important symptoms and effects, both acute and delayed

No information available

4.3 Indication of any immediate medical attention and special treatment needed.

No information available

5. FIRE FIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media

Water spray, carbon dioxide, dry chemical powder or foam

5.2 Special hazards arising from the substance or mixture

No information available

5.3 Advice for firefighters

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions,protective equipment and emergency procedures

Use full personal protective equipment. Evacuate personnel to safe areas.

6.2 Environmental precautions

Prevent further leakage or spillage. Prevent product from entering drain.

6.3 Methods and material for containment and cleaning up

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE

7.1 Precautions for safe handling

Avoid skin/eye contact. Use protective equipment as needed. Wash contaminated clothing before reuse.

7.2 Conditions for safe storage,including any incompatibilities

Keep container tightly closed in a cool,well-vented place. Store at -20˚C.

7.3 Specific end use(s)

No data available.

8. EXPOSURE CONTROLS/PERSONAL INFORMATION

8.1 Control Parameters

This product contains no hazardous materials with occupational exposure limits.

8.2 Exposure controls

Engineering controls

Provide shower and eye wash station

Personal protective equipment

Eye Protection

Wear safety goggles

Skin Protection

Wear protective clothing

Hand Protection

Wear protective gloves

Respiratory protection

Wear NIOSH/MSHA approved respirators

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

Appearance

Solid

pH

No data available

Melting point

No data available

Freezing point

No data available

Boiling point

No data available

Density

No data available

Water solubility

Insoluble

9.2 Other safety information

No data available.

10. STABILITY AND REACTIVITY

10.1Reactivity

No data available

10.2Chemical stability

Stable under recommended storage conditions.

10.3Possibility of hazardous reactions

No data available.

10.4Conditions to avoid

Protect from light and heat

10.5Incompatible materials

Strong oxidizing agents

10.6Hazardous decomposition products

Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION

11.1Information on toxicological effects

Toxicological effects on this product have not been thoroughly studied.

12. ECOLOGICAL INFORMATION

12.1Toxicity

Avoid release into environment

12.2Persistence and degradability

No data available

12.3.Bioaccumulative potential

No data available

12.4Mobility in soil

No data available

12.5Results of PBT and vPvB assessment

No data available

12.6Other adverse effects

No data available

13. DISPOSAL INFORMATION

13.1Waste treatment methods

Dispose in accordance with local, state, and federal regulations.

14. TRANSPORT INFORMATION

DOT:

UN number:2811 Class:6.1,Packing group:III
Proper shipping name: Toxic solids,organic,n.o.s(FK506)

Marin pollutant:No

Poison Inhalation Hazard:No


IATA:
UN number:2811 Class:6.1,Packing group:III
Proper shipping name: Toxic solids, organic, n.o.s(FK506)

IMDG
UN number:2811 Class:6.1,Packing group:III

EMS-No:F-A,S-A
Proper shipping name: TOXIC SOLID, ORGANIC,N.O.S(FK506)

Marine pollutant:No

15. REGULATORY INFORMATION

EU Risk and Safety phrases:

R25: Toxic if swallowed

S22: Do not breathe dust

S24/25: Avoid contact with skin and eyes

S36/37/39:Wear suitable protective clothing,gloves and eye/face protection

16. OTHER INFORMATION

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.

John H. Boyd, Maziar Divangahi, Linda Yahiaoui, Dusanka Gvozdic, Salman Qureshi, and Basil J. Petrof. MOLECULAR PATHOGENESIS:Toll-Like Receptors Differentially Regulate CC and CXC Chemokines in Skeletal Muscle via NF-kappa B and Calcineurin Infect. Immun.,Dec 2006; 74: 6829 - 6838.

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Eton Bioscience, Inc.
5820 Oberlin Drive, Suite 108
San Diego, CA 92121
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