Cyclosporin D

Cyclosporin D, Val2-cyclosporine. Nonpolar cyclic oligopeptide with immunosuppressant activity.

Sku #Product NameProduct SizePriceQTY
1100040012 Cyclosporin D 1 mg 1 mg $70.00 USD
1100040052 Cyclosporin D 5 mg 5 mg $290.00 USD
 

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Molecular Formula: C63H113N11O12
Molecular Weight: 1216.63g/mol
Synonym: Val2-Cyclosporin
CAS Number: 63775-96-2
Appearance: White powder
Solubility: Soluble in methanol, ethanol, acetone, ether, chloroform. Insoluble in water.
Purity: 95%
Applications: Immunosuppressant


Material Safety Data Sheet

Date:Oct 26,2015

1. PRODUCT AND COMPANY IDENTIFICATION

1.1 Product identifier

Product name: Cyclosporin D

Catalog No:1100040012,1100040052

1.2 Relevant identified uses of the substance or mixture and uses advised against

For research use only.

1.3 Details of the supplier of the safety data sheet

Company:Eton Bioscience Inc

TollFree:1-800-758-1630

Tel:1-800-758-1630

Fax:1-800-507-2912

1.4 Emergency telephone number

1-800-758-1630

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Acute Toxicity,Oral,Category 4

Carcinogenicity,Category 1A

Reproductive toxicity,Category 1A

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal Word

Danger

Hazard Statement

H302

H350

Harmful if swallowed

May cause cancer

H360

May damager fertility or the unborn child

Precautionary statement

P264

Wash skin thoroughly after handling

P301+P312

IF SWALLOED:Call a POISON CENTER or doctor/physician if you feel unwell

P330

Rinse mouth

P501

Dispose of contents/container to an approved waste disposal plant

2.3 Other hazards

None

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Molecular Formula: C63H113N11O12

Molecular Weight:1216.63g/mol

CAS No:109581-93-3

4. FIRST AID MEASURES

4.1 Description of first aid measures

Eye contact

Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician

Skin Contact

Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician

Inhalation

If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration

Ingestion

If swallowed, wash out mouth with copious amounts of water; call a physician

4.2 Most important symptoms and effects, both acute and delayed

No information available

4.3 Indication of any immediate medical attention and special treatment needed.

No information available

5. FIRE FIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media

Water spray, carbon dioxide, dry chemical powder or foam

5.2 Special hazards arising from the substance or mixture

No information available

5.3 Advice for firefighters

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions,protective equipment and emergency procedures

Use full personal protective equipment. Evacuate personnel to safe areas.

6.2 Environmental precautions

Prevent further leakage or spillage. Prevent product from entering drain.

6.3 Methods and material for containment and cleaning up

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE

7.1 Precautions for safe handling

Avoid skin/eye contact. Use protective equipment as needed. Wash contaminated clothing before reuse.

7.2 Conditions for safe storage,including any incompatibilities

Keep container tightly closed in a cool,well-vented place. Store at -20˚C.

7.3 Specific end use(s)

No data available.

8. EXPOSURE CONTROLS/PERSONAL INFORMATION

8.1 Control Parameters

This product contains no hazardous materials with occupational exposure limits.

8.2 Exposure controls

Engineering controls

Provide shower and eye wash station

Personal protective equipment

Eye Protection

Wear safety goggles

Skin Protection

Wear protective clothing

Hand Protection

Wear protective gloves

Respiratory protection

Wear NIOSH/MSHA approved respirators

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

Appearance

Solid

pH

No data available

Melting point

No data available

Freezing point

No data available

Boiling point

No data available

Density

No data available

Water solubility

Insoluble

9.2 Other safety information

No data available.

10. STABILITY AND REACTIVITY

10.1Reactivity

No data available

10.2Chemical stability

Stable under recommended storage conditions.

10.3Possibility of hazardous reactions

No data available.

10.4Conditions to avoid

Protect from light and heat

10.5Incompatible materials

Strong oxidizing agents

10.6Hazardous decomposition products

Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION

11.1Information on toxicological effects

Toxicological effects on this product have not been thoroughly studied.

12. ECOLOGICAL INFORMATION

12.1Toxicity

Avoid release into environment

12.2Persistence and degradability

No data available

12.3.Bioaccumulative potential

No data available

12.4Mobility in soil

No data available

12.5Results of PBT and vPvB assessment

No data available

12.6Other adverse effects

No data available

13. DISPOSAL INFORMATION

13.1Waste treatment methods

Dispose in accordance with local, state, and federal regulations.

14. TRANSPORT INFORMATION

DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport


IATA:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

IMDG:

Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATORY INFORMATION

EU Risk and Safety phrases:

R22: Harmful if swallowed

R45:May cause cancer

R60:May impair fertility

R61:May cause harm to the unborn child

S22: Do not breathe dust

S24/25: Avoid contact with skin and eyes

S36/37/39:Wear suitable protective clothing,gloves and eye/face protection

16. OTHER INFORMATION

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.

Wilhelm,AJ.den Burge,J.C.G. Vos,R.M. Chahbouni,A.Sinjewel.A.Analysis of cyclosporin A in dried blood spots using liquid chromatography tandem mass spectrometry. Journal of Chromatograhy B,volume 877(2009)1595-1598.

Hiroto Kambara,Hideki Tani,Yoshio Mori, Takayuki Abe,Hiroshi Katoh,Takasuke Fukuhara,Shuhei Tagura,Kohji Moriishi,Yoshiharu Matsuura.Involvement of cyclophilin B in the replication of Japanese encephalitis virus. Virology. 2011 Mar 30;412(1):211-9. doi: 10.1016/j.virol.2011.01.011. Epub 2011 Feb 1.

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Eton Bioscience, Inc.
5820 Oberlin Drive, Suite 108
San Diego, CA 92121
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